My Teaching & Research

My Teaching
I have been a demonstrator in neuro-anatomy and a lecturer at Brighton & Sussex Medical School. I have lectured on sleep disorders nationally.  I currently lecture to Medical Students on the Neueoscience & behaviour modue at Brighton & Sussex Medical School.  I also give regular lectures to GP’s and teach Neurology to training grade Neurologists.

My Research
I have published laboratory-based research in Parkinson’s Disease at The Institute of Neurology & The Parkinson’s Disease Society Brain Bank & in London. This involved the use of in situ hybridization of neurotransmitter mRNAs in various brain basal ganglia regions in post-mortem Parkinson’s disease brains.  I am currently undertaking studies in patients with the non-REM parasomnia spectrum (sleep walking, night terrors, confusional arousals etc).

Selected Papers (PDF Format)
Sleep walking
BMJ Lesson of the Week – Diaphragm Paralysis
Discovery of Nitric Oxide Neurons in the Subthalamic Nucleus
Basal ganglia enkephalin & substance-P mRNA expression in human Parkinson’s disease
Basal ganglia GAD-67 mRNA expression in human Parkinson’s disease

All My Publications
1. A.P. NISBET and C.A. MARSDEN (1984)
Increased behavioural response to 5-methoxy-n,n-dimethyl-tryptamine, but not to RU 24969, after intra-ventricular 5,7-dihydroxy-tryptamine administration.
European Journal of pharmacology, 104, 177-180.

2. M.P. BRAZELL, C.A. MARSDEN, A.P. NISBET and C. ROUTLEDGE (1985)
The 5-HT receptor agonist RU-24969 decreases 5-hydroxytryptamine (5-HT) release and metabolism in the rat frontal cortex in vitro and in vivo.
British Journal of Pharmacology, 86, 209-216.

3. A.P. NISBET, W. KINEAR and M.J. WARD (1991)
Bilateral diaphragmatic paralysis may present with orthopnoea and apparent radiological evidence of pulmonary emboli.
British Medical Journal, 302, 954-955.

4. A.P.NISBET, O.J.F. FOSTER, A. KINGSBURY, A.J.LEES, C.D. MARSDEN (1994)
Nitric oxide synthase mRNA expression in human subthalamic nucleus, striatum and globus pallidus: implications for basal ganglia function.
Brain Res. Mol. Brain Res., 22: 329-332

5. A.P.NISBET, O.J.F. FOSTER, A. KINGSBURY, A.J.LEES (1994)
Regional striatal neuropeptide expression in Parkinson’s disease: a quantitative in situ hybridisation study (Abstract)
New Trends in Clinical Neuropharmacology, 7 (N.1): 60.

6. A.P.NISBET, O.J.F. FOSTER, A. KINGSBURY, C.D. MARSDEN, A.J.LEES (1994)
Nitric oxide synthase mRNA expression in parkinsonian basal ganglia: A Quantitative In Situ Hybridization Study (Abstract)
Mov.Disord. 9 (Suppl.1): 103

7. A. KINGSBURY, O.J.F. FOSTER, A.P. NISBET, N. CAIRNS, L. BRAY, D.J. EVE, A.J.LEES, C.D. MARSDEN (1995)
Tissue pH as an indicator of mRNA preservation in human post-mortem brain.
Mol.Brain Res. 28: 311-318

8. A.P. NISBET, O.J.F. FOSTER, A. KINGSBURY, D.J. EVE, S.E. DANIEL,C.D. MARSDEN, A.J.LEES (1995)
Pre-proenkephalin and pre-protachykinin mRNA expression in normal human basal ganglia and in Parkinson’s disease.
Neuroscience 66: 361-376

9. D.J. EVE, A.P.NISBET, A.KINGSBURY, C.D. MARSDEN, O.J.FOSTER (1995)
Somatostatin mRNA expression in parkinsonian basal ganglia. A quantitative in situ hybridization study (Abstract).
Soc.Neurosci.Abs. 21: 1251

10. A.P. NISBET, D.J. EVE, A. KINGSBURY, S.E. DANIEL, C.D. MARSDEN, A.J.LEES, O.J.F. FOSTER (1996)
Glutamate decarboxylase-67 messenger RNA expression in normal human basal ganglia and in Parkinson’s disease.
Neuroscience 75: 389-406

11. A.P. NISBET, C. DAVENPORT, I. TODD, J.M. DAVIES,A.M. WHITELEY (1996)
Paraneoplastic ‘stiff-man syndrome plus’ associated with an IgM kappa-secreting non-Hodgkin’s lymphoma (Abstract).
Mov.Disord. 11 (Suppl 1.): 235

12. B.S. ATHWAL, A.P. NISBET, D. JEFFERSON (1996)
Diaphragmatic flutter associated with an intramedullary cervical cord tumour (Abstract).
Mov.Disord. 11 (Suppl 1.): 98

13. A.P. NISBET, N.J. SMITH, R.B. GODWIN-AUSTEN (1996)
Aquired epileptic expressive dysphasia in a sinistral patient associated with increased ictal 99mTc-HMPAO uptake in the right fronto-temporal region (Abstract).
Eur.J.Neurology 3 (suppl 5): 143

14. A.P. NISBET, S.E. DANIEL, A.J. LEES (1996)
Arteriosclerotic Parkinsonism (Abstract).
J.Neurol.Neurosurg.Psychiatry 61: 537

15. D.J. EVE, A.P. NISBET, A. KINGSBURY, C.D. MARSDEN, O.J.F. FOSTER (1997)
Increased nitric oxide expression within the the subthalamic nucleus in Parkinson’s disease (Abstract).
Mov.Disord. 12 (Suppl 1.): 115

16. EVE DJ, NISBET AP, KINGSBURY AE, TEMLETT J, MARSDEN CD, FOSTER OJ. (1997)
Selective increase in somatostatin mRNA expression in human basal ganglia in Parkinson’s disease.
Brain Res Mol Brain Res. 1997: 50(1-2): 59-70.

17. EVE DJ. NISBET AP. KINGSBURY AE. HEWSON EL. DANIEL SE. LEES AJ. MARSDEN CD. FOSTER OJ. (1998)
Basal ganglia neuronal nitric oxide synthase mRNA expression in Parkinson’s disease.
Brain Research. Molecular Brain Research. 63(1):62-71, 1998

18. ONG GL, RIPLEY LG, NISBET AP (2000)
Temporal Modulation (8Hz Flicker) Enhances the Difference in Achromatic Contrast Sensitivity Between Parkinson’s Disease Patients and Controls Especially at Low Spatial Frequency.
Movement Disorder; 15 (Suppl 3):82

19. ONG GL, NISBET AP, HADDRELL NR, BRADLEY VA, RIPLEY LG (1999)
Levodopa Responsiveness of Contrast Sensitivity in Different Parkinsonian Syndromes.
Parkinsonism & Related Disorders; 5 (Suppl):S39

20. FORBES A, BRECHANY U, STEGIE F, STUTT A, CHAUDHURI KR, APPIAH-KUBI LS, NISBET A, BURN DJ
Use and Tolerability of Cabergoline in Young and Older People with Parkinson’s Disease: A Multi-Center Observational Study
The Journal of Applied Research Vol. 3 (4), 2003

21. DAS R, MOLLOY J, NISBET A
Acute onset new variant creutzfeld-jakob disease in a compulsive jelly eater
J. Neurol. Neurosurg. Psychiatry 2002;73;223

22. ANDERSON S, NISBET A, DAS R, MALLOY J
A case study in variant CJD
Archives of Clinical Neuropsychology 19 (2004) 847

23. HARRISON NA, CHURCH A, NISBET A, RUDGE P, GIOVANNONI G.
Late recurrences of Sydenham’s chorea are not associated with anti-basal ganglia antibodies.
J Neurol Neurosurg Psychiatry. 2004 Oct;75(10):1478-9

24. HARPER A, BAYLISS M, SAHA R, SCUTT A, NISBET A
Late onset dopa-responsive dystonia with tremor, gait freezing and behavioural disturbance and a normal dopamine transporter scan
Age Ageing. 2008 Nov;37(6):719-20

25. E. BROUGHTON, A. GRICKS, S. BAYNES, A. NISBET
Comparing a bedside timed motor assessment tool (BT-MAT) with the UPDRS- III to measure clinical features and l-dopa response in parkinson’s disease

26. KAREN M DOHERTY, ALASTAIR J NOYCE, LAURA SILVEIRA-MORIYAMA, ANGUS NISBET, NIALL QUINN, ANDREW J LEES
Familial camptocormia: from dystonia to myopathy
J Neurol Neurosurg Psychiatry. 2012 Mar;83(3):350-1

27. BANERJEE D, NISBET A.
Sleepwalking.
Sleep Med Clin. 2011 6 (4): 401–416.

28. LAURA MANTOAN SOFIA H ERIKSSON ANGUS P NISBET MATTHEW C WALKER
Adult-onset Non-REM Parasomnia with Hypnopompic Hallucinatory Pain: a Case Report
Sleep. 2013 Feb 1;36(2):287-90.
29. BREJT N, BERRY J, NISBET A, BLOOMFIELD D, BURKILL G.
Pelvic radiculopathies, lumbosacral plexopathies, and neuropathies in oncologic disease: a multidisciplinary approach to a diagnostic challenge.
Cancer Imaging. 2013 Dec 30;13(4):591-601.